Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.

doi:10.1016/j.ophtha.2012.03.014

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Article

Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.

Ophthalmology - 1 Sept 2012

Sobrin Lucia, Ripke Stephan, Yu Yi, Fagerness Jesen, Bhangale Tushar R, Tan Perciliz L, Souied Eric H, Buitendijk Gabriëlle H S, Merriam Joanna E, Richardson Andrea J, Raychaudhuri Soumya, Reynolds Robyn, Chin Kimberly A, Lee Aaron Y, Leveziel Nicolas, Zack Donald J, Campochiaro Peter, Smith R Theodore, Barile Gaetano R, Hogg Ruth E, Chakravarthy Usha, Behrens Timothy W, Uitterlinden André G, van Duijn Cornelia M, Vingerling Johannes R, Brantley Milam A, Baird Paul N, Klaver Caroline C W, Allikmets Rando, Katsanis Nicholas, Graham Robert R, Ioannidis John P A, Daly Mark J, Seddon Johanna M

Abstract excerpt

PURPOSE: To investigate whether the 2 subtypes of advanced age-related macular degeneration (AMD), choroidal neovascularization (CNV), and geographic atrophy (GA) segregate separately in families and to identify which genetic variants are associated with these 2 subtypes. DESIGN: Sibling correlation study and genome-wide association study (GWAS). PARTICIPANTS: For the sibling correlation study, 209 sibling pairs...

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Identifiers

PMID: 22705344
DOI: 10.1016/j.ophtha.2012.03.014
PMCID: PMC3899891

Genes

ARMS2
HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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