Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for a phenotypic switch in corneal afferents after lacrimal gland excision.

Experimental eye research - 1 May 2022

Sullivan Cara, Lee Jun, Bushey William, Demers Danielle, Dinsdale Samantha, Lowe Katy, Olmeda Jessica, Meng Ian D

Abstract excerpt

Dry eye is a common cause of ocular pain. The aim of this study was to investigate corneal innervation, ongoing pain, and alterations in corneal afferent phenotypes in a mouse model of severe aqueous tear deficiency. Chronic dry eye was produced by ipsilateral excision of the extra- and intraorbital lacrimal glands in male and female mice. Tearing was measured using a phenol thread and corneal epithelial damage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcitonin Gene-Related Peptide
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to TRPV Cation Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 35240196
DOI: 10.1016/j.exer.2022.109005
PMCID: PMC9993327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for a phenotypic switch in corneal afferents after lacrimal gland excision.PMID 35240196Read ↗

A transient receptor potential vanilloid 1-dependent corneal-trigeminal neuroinflammatory circuit promotes corneal neuropathySemantic proximity Read ↗

A transient receptor potential vanilloid 1-dependent corneal-trigeminal neuroinflammatory circuit promotes corneal neuropathySemantic proximity Read ↗

CD4 <sup>+</sup> T cells drive corneal nerve damage but not epitheliopathy in an acute aqueous-deficient dry eye modelSemantic proximity Read ↗

Essential roles of sensory nerve in maintenance of cornea-phenotype in mice.Semantic proximity Read ↗

Intrinsic Regeneration Mechanisms of Murine Lacrimal Gland Epithelial Cells for Therapeutic Applications in Aqueous- Deficient Dry Eye DiseaseSemantic proximity Read ↗

Opsin 5 mediates violet light-accelerated wound healing in mammalian corneasSemantic proximity Read ↗

Pitx2-associated early-onset glaucoma alters corneal innervation and sensory function in a sex-specific mannerSemantic proximity Read ↗

Targeting α7 Nicotinic Acetylcholine Receptor for Modulating the Neuroinflammation of Dry Eye Disease via MacrophageSemantic proximity Read ↗

AAV2/9-mediated gene transfer into murine lacrimal gland leads to a long-term targeted tear film modificationSemantic proximity Read ↗

Inherited mitochondrial dysfunction triggered by OPA1 mutation impacts the sensory innervation fibre identity, functionality and regenerative potential in the cornea.Semantic proximity Read ↗

Topographical Distribution and Phenotype of Resident Meibomian Gland Orifice Immune Cells (MOICs) in Mice and the Effects of Topical Benzalkonium Chloride (BAK).Semantic proximity Read ↗

Ion Channels in the Eye: Involvement in Ocular Pathologies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.