Article

A transient receptor potential vanilloid 1-dependent corneal-trigeminal neuroinflammatory circuit promotes corneal neuropathy

2025-06-20

Abstract excerpt

<title>Abstract</title> <p>Corneal neurosensory abnormalities cause pain and discomfort in ocular surface disease, yet their pathophysiology is poorly understood. Here, we show that in a mouse dry eye model, ocular (over)activation of transient receptor potential vanilloid-1 (TRPV1) channels in response to tear deficiency and tissue damage promotes neuroinflammatory gene expression and macrophage reactivivity in...

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Literature Corpus work: d65194ce-fce4-5c76-ade0-ad8d4c044237
DOI: 10.21203/rs.3.rs-6916662/v1

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