Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression.

doi:10.1126/scitranslmed.aad6066

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression.

Science translational medicine - 3 Aug 2016

Yong Kol Jia, Basseres Daniela S, Welner Robert S, Zhang Wen Cai, Yang Henry, Yan Benedict, Alberich-Jorda Meritxell, Zhang Junyan, de Figueiredo-Pontes Lorena Lobo, Battelli Chiara, Hetherington Christopher J, Ye Min, Zhang Hong, Maroni Giorgia, O'Brien Karen, Magli Maria Cristina, Borczuk Alain C, Varticovski Lyuba, Kocher Olivier, Zhang Pu, Moon Young-Choon, Sydorenko Nadiya, Cao Liangxian, Davis Thomas W, Thakkar Bhavin M, Soo Ross A, Iwama Atsushi, Lim Bing, Halmos Balazs, Neuberg Donna, Tenen Daniel G, Levantini Elena

Abstract excerpt

Lung cancer is the most common cause of cancer deaths. The expression of the transcription factor C/EBPα (CCAAT/enhancer binding protein α) is frequently lost in non-small cell lung cancer, but the mechanisms by which C/EBPα suppresses tumor formation are not fully understood. In addition, no pharmacological therapy is available to specifically target C/EBPα expression. We discovered a subset of pulmonary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adenocarcinoma of Lung

Share to CCAAT-Enhancer-Binding Protein-alpha

Share to Gene Expression Regulation, Neoplastic

Share to Lung Neoplasms

Share to Mice, Knockout

Share to Polycomb Repressive Complex 1

Share to Proto-Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27488898
DOI: 10.1126/scitranslmed.aad6066
PMCID: PMC8214331

Genes

BMI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression.PMID 27488898Read ↗

C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transitionSemantic proximity Read ↗

LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancerSemantic proximity Read ↗

Respiratory Failure Due to Differentiation Arrest and Expansion of Alveolar Cells following Lung-Specific Loss of the Transcription Factor C/EBPα in MiceSemantic proximity Read ↗

Loss of the SWI/SNF ATPase subunits BRM and BRG1 drives lung cancer developmentSemantic proximity Read ↗

MYC-MIZ1 Complexes at Enhancers Tune Neuroendocrine Identity of Small Cell Lung CancerSemantic proximity Read ↗

Decoding c-Myc networks of cell cycle and apoptosis regulated genes in a transgenic mouse model of papillary lung adenocarcinomas.Semantic proximity Read ↗

Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast CancerSemantic proximity Read ↗

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.Semantic proximity Read ↗

NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancerSemantic proximity Read ↗

HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53Semantic proximity Read ↗

Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in PatientsSemantic proximity Read ↗

Genetic ablation of CCAAT/enhancer binding protein alpha in epidermis reveals its role in suppression of epithelial tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.