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Article

Limited Metabolic Effect of the CREBRFR457Q Obesity Variant in Mice.

Cells - 31 Jan 2022

Metcalfe Louise K, Shepherd Peter R, Smith Greg C, Turner Nigel

Abstract excerpt

The Arg457Gln missense variant in the CREBRF gene has previously been identified as driving excess body weight in Pacific/Oceanic populations. Intriguingly, Arg457Gln variant carriers also demonstrate paradoxical reductions in diabetes risk, indicating that the gene has a critical role in whole-body metabolism. To study the function of this variant in more detail, we generated mice on an FVB/N background with the...

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PMID: 35159305
DOI: 10.3390/cells11030497
PMCID: PMC8833978

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Limited Metabolic Effect of the CREBRFR457Q Obesity Variant in Mice.PMID 35159305Read ↗

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