Article
Mutation in atpE and Rv0678 genes associated with bedaquline resistance among drug-resistant tuberculosis patients: A pilot study from a high-burden setting in Northern India.
International journal of mycobacteriology - 1 Jan 2000
Singh Binit Kumar, Soneja Manish, Sharma Rohini, Chaubey Jigyasa, Kodan Parul, Jorwal Pankaj, Nischal Neeraj, Chandra Shivani, Ramachandran Ranjani, Wig Naveet
Abstract excerpt
Background: Mutations in atpE gene or transcriptional repressor Rv0678 gene associated with inhibition of adenosine 5'-triphosphate synthase and upregulation of efflux pumps, respectively, may potentially lead to in vitro resistance to bedaquiline. This is the first study from India, which looks at mutations associated with this novel drug. Methods: In 2019 (January to June), a total of 68 laboratory-confirmed...
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