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Article

SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis.

Translational research : the journal of laboratory and clinical medicine - 1 Jul 2022

Zhong Hua, Zhou Zhihong, Guo Lebin, Liu Fu-Sheng, Wang Xiaobin, Li Jing, Lv Guo-Hua, Zou Ming-Xiang

Abstract excerpt

Long noncoding RNAs (lncRNAs) and miRNAs have been reported to participate in intervertebral disc degeneration (IDD) progression. However, the key lncRNA-miRNA axis and its corresponding affected hub genes in IDD remain unknown. In this study, weighted gene coexpression network analysis (WGCNA) was first used to determine the key gene cluster and hub genes implicated in IDD progression. The expression levels of...

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PMID: 35196590
DOI: 10.1016/j.trsl.2022.02.006

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