Article

Silencing NDC80, RAD21 and BUB1B ameliorates intervertebral disc degeneration by promoting proliferation and inhibiting apoptosis of nucleus pulposus cells

2020-06-19

Abstract excerpt

<h4>Background: </h4> Intervertebral disc degeneration (IVDD) is a commonly occurring musculoskeletal disorder, which is closely associated with low back pain. Accumulating evidence has demonstrated that dysregulated genes expression profiles play important roles in pathogenesis of IVDD. Hence, the current study was aimed to identify key genes to understand underlying mechanisms and therapeutic targets of IVDD. Me...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 50e5f299-d910-53a3-bb44-653efa314953
DOI: 10.21203/rs.3.rs-31592/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Silencing NDC80, RAD21 and BUB1B ameliorates intervertebral disc degeneration by promoting proliferation and inhibiting apoptosis of nucleus pulposus cellsDOI 10.21203/rs.3.rs-31592/v1Read

The role of miRNA, lncRNA and circRNA in the development of intervertebral disk degeneration (Review)Semantic proximity Read

SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis.Semantic proximity Read

Role of microRNAs in intervertebral disc degeneration (Review)Semantic proximity Read

Identification of Core Genes and Screening of Potential Targets in Intervertebral Disc Degeneration Using Integrated Bioinformatics AnalysisSemantic proximity Read

WITHDRAWN: The expression of LCN2 in lumbar disc herniation was verified by bioinformatics analysis and protein blotSemantic proximity Read

The Mechanism and Function of <scp>miRNA</scp> in Intervertebral Disc DegenerationSemantic proximity Read

Progress in the study of molecular mechanisms of intervertebral disc degenerationSemantic proximity Read

Circ_0040039 May Aggravate Intervertebral Disk Degeneration by Regulating the MiR-874-3p-ESR1 PathwaySemantic proximity Read

Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degenerationSemantic proximity Read

Bioinformatics-Based Discovery of Intervertebral Disc Degeneration Biomarkers and Immune- Inflammatory InfiltratesSemantic proximity Read

S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo studySemantic proximity Read

Integrated proteome sequencing, bulk RNA sequencing and single-cell RNA sequencing to identify potential biomarkers in different grades of intervertebral disc degenerationSemantic proximity Read