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Article

Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core

22 Feb 2022

Abstract excerpt

The molecular events that permit the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to bind and enter cells are important to understand for both fundamental and therapeutic reasons. Spike proteins consist of S1 and S2 domains, which recognize angiotensin-converting enzyme 2 (ACE2) receptors and contain the viral fusion machinery, respectively. Ostensibly, the binding of spike...

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PMID: 35194049
DOI: 10.1038/s41467-022-28654-5

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