Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Patterns of cell division and the risk of cancer.

Genetics - 1 Apr 2003

Frank Steven A, Iwasa Yoh, Nowak Martin A

Abstract excerpt

Epidermal and intestinal tissues divide throughout life to replace lost surface cells. These renewing tissues have long-lived basal stem cell lineages that divide many times, each division producing one stem cell and one transit cell. The transit cell divides a limited number of times, producing cells that move up from the basal layer and eventually slough off from the surface. If mutation rates are the same in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cell Division
Share to Epithelium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Biological

Share to Mutation

Share to Neoplasms

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 12702695
DOI: 10.1093/genetics/163.4.1527
PMCID: PMC1462514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Patterns of cell division and the risk of cancer.PMID 12702695Read ↗

Effect of stem cell turnover rates on protection against cancer and aging.Semantic proximity Read ↗

Why do stem cells exist?Semantic proximity Read ↗

The Stem Cell Division Theory of CancerSemantic proximity Read ↗

The stem cell division theory of cancer.Semantic proximity Read ↗

Constrained optimization of divisional load in hierarchically organized tissues during homeostasis.Semantic proximity Read ↗

Pathways to tumorigenesis--modeling mutation acquisition in stem cells and their progeny.Semantic proximity Read ↗

Mathematical models of tissue stem and transit target cell divisions and the risk of radiation- or smoking-associated cancer.Semantic proximity Read ↗

Cancer, aging and the optimal tissue design.Semantic proximity Read ↗

Cancer Risk and the Somatic Cell Lineage TreeSemantic proximity Read ↗

Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions.Semantic proximity Read ↗

The role of cell location and spatial gradients in the evolutionary dynamics of colon and intestinal crypts.Semantic proximity Read ↗

Minimizing the risk of cancer: tissue architecture and cellular replication limitsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.