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Article

Genome-wide meta-analyses identify five new risk loci for nonsyndromic orofacial clefts in the Chinese Han population.

Molecular genetics & genomic medicine - 1 Oct 2023

Yu Yafen, Zhen Qi, Chen Weiwei, Yu Yanqin, Li Zhuo, Wang Yirui, Fan Wencheng, Luo Sihan, Wang Daiyue, Bai Yuanming, Bian Zhuan, He Miao, Sun Liangdan

Abstract excerpt

BACKGROUND: Nonsyndromic orofacial clefts (NSOFCs) are the most common craniofacial birth malformations in humans and are generally classified as nonsyndromic cleft lip with or without cleft palate (NSCL/P) and nonsyndromic cleft palate only (NSCPO). Genome-wide association studies (GWASs) of NSOFCs have demonstrated multiple risk loci and candidate genes; however, published risk factors are able to explain only...

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PMID: 37326468
DOI: 10.1002/mgg3.2226
PMCID: PMC10568389

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