Recurrent Fusion of the Genes for High-mobility Group AT-hook 2 (<i>HMGA2</i>) and Nuclear Receptor Co-repressor 2 (<i>NCOR2</i>) in Osteoclastic Giant Cell-rich Tumors of Bone

Abstract excerpt

BACKGROUND/AIM: Chimeras involving the high-mobility group AT-hook 2 gene (HMGA2 in 12q14.3) have been found in lipomas and other benign mesenchymal tumors. We report here a fusion of HMGA2 with the nuclear receptor co-repressor 2 gene (NCOR2 in 12q24.31) repeatedly found in tumors of bone and the first cytogenetic investigation of this fusion. MATERIALS AND METHODS: Six osteoclastic giant cell-rich tumors were...

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