Identification of a novel, recurrent <i>HEY1‐NCOA2</i> fusion in mesenchymal chondrosarcoma based on a genome‐wide screen of exon‐level expression data

Abstract excerpt

Cancer gene fusions that encode a chimeric protein are often characterized by an intragenic discontinuity in the RNA\expression levels of the exons that are 5' or 3' to the fusion point in one or both of the fusion partners due to differences in the levels of activation of their respective promoters. Based on this, we developed an unbiased, genome-wide bioinformatic screen for gene fusions using Affymetrix Exon...

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