Recurrent t(2;2) and t(2;8) translocations in rhabdomyosarcoma without the canonical <i>PAX‐FOXO1</i> fuse <i>PAX3</i> to members of the nuclear receptor transcriptional coactivator family

Abstract excerpt

The fusion oncoproteins PAX3-FOXO1 [t(2;13)(q35;q14)] and PAX7-FOXO1 [t(1;13)(p36;q14)] typify alveolar rhabdomyosarcoma (ARMS); however, 20-30% of cases lack these specific translocations. In this study, cytogenetic and/or molecular characterization to include FISH, reverse transcription polymerase chain reaction (RT-PCR), and sequencing analyses of five rhabdomyosarcomas [four ARMS and one embryonal...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related gene regulation
• Share to Genomics and Chromatin Dynamics
• Share to Sarcoma Diagnosis and Treatment