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Article

Potential role of regulatory DNA variants in modifying the risk of severe cutaneous reactions induced by aromatic anti-seizure medications.

Epilepsia - 1 Apr 2022

Mullan Kerry A, Anderson Alison, Shi Yi-Wu, Ding Jia-Hong, Ng Ching-Ching, Chen Zhibin, Baum Larry, Cherny Stacey, Petrovski Slave, Sham Pak C, Lim Kheng-Seang, Liao Wei-Ping, Kwan Patrick

Abstract excerpt

OBJECTIVE: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions. Antiseizure medications (ASMs) with aromatic ring structure, including carbamazepine, are among the most common culprits. Screening for human leukocyte antigen (HLA) allele HLA-B*15:02 is recommended prior to initiating treatment with carbamazepine in Asians, but this allele has low positive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35170024
DOI: 10.1111/epi.17182
PMCID: PMC9541367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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