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Unraveling the genetic link: an umbrella review on HLA-B*15:02 and antiepileptic drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.

Pharmacogenetics and genomics - 1 Jul 2024

Tham Kar Mun, Yek Jacklyn Jia Lin, Liu Christopher Wei Yang

Abstract excerpt

PURPOSE: This umbrella review was conducted to summarize the association between HLA*1502 allele with antiepileptic induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). METHODS: Pubmed, Scopus and EMBASE were searched for eligible reviews in May 2023. Two authors independently screened titles and abstracts and assessed full-text reviews for eligibility. The quality of meta-analyses and...

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Alleles
Anticonvulsants
Carbamazepine
Genetic Predisposition to Disease
HLA-B15 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stevens-Johnson Syndrome

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PMID: 38527170
DOI: 10.1097/FPC.0000000000000531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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