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Cyclic Diguanylate Regulates Virulence Factor Genes via Multiple Riboswitches in Clostridium difficile

23 Oct 2018

Abstract excerpt

In Clostridium difficile , the signaling molecule c-di-GMP regulates multiple processes affecting its ability to cause disease, including swimming and surface motility, biofilm formation, toxin production, and intestinal colonization. In this study, we used RNA-seq to define the transcriptional regulon of c-di-GMP in C. difficile . Many new targets of c-di-GMP regulation were identified, including multiple...

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PMID: 30355665
DOI: 10.1128/msphere.00423-18

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