Article
Metabolomic and Gene Expression Profiles Exhibit Modular Genetic and Dietary Structure Linking Metabolic Syndrome Phenotypes in Drosophila.
G3 (Bethesda, Md.) - 3 Nov 2015
Williams Stephanie, Dew-Budd Kelly, Davis Kristen, Anderson Julie, Bishop Ruth, Freeman Kenda, Davis Dana, Bray Katherine, Perkins Lauren, Hubickey Joana, Reed Laura K
Abstract excerpt
Genetic and environmental factors influence complex disease in humans, such as metabolic syndrome, and Drosophila melanogaster serves as an excellent model in which to test these factors experimentally. Here we explore the modularity of endophenotypes with an in-depth reanalysis of a previous study by Reed et al. (2014), where we raised 20 wild-type genetic lines of Drosophila larvae on four diets and measured...
Topics
- Animal Feed
- Animals
- Cluster Analysis
- Drosophila
- Gene Expression Profiling
- Gene Expression Regulation
- Genetic Association Studies
- Genetics, Population
- Genotype
- Metabolic Syndrome
- Metabolome
- Metabolomics
- Phenotype