Article
Causal associations of genetic factors with clinical progression in amyotrophic lateral sclerosis.
Computer methods and programs in biomedicine - 1 Apr 2022
Ahangaran Meysam, Chiò Adriano, D'Ovidio Fabrizio, Manera Umberto, Vasta Rosario, Canosa Antonio, Moglia Cristina, Calvo Andrea, Minaei-Bidgoli Behrouz, Jahed-Motlagh Mohammad-Reza
Abstract excerpt
BACKGROUND AND OBJECTIVE: Recent advances in the genetic causes of ALS reveals that about 10% of ALS patients have a genetic origin and that more than 30 genes are likely to contribute to this disease. However, four genes are more frequently associated with ALS: C9ORF72, TARDBP, SOD1, and FUS. The relationship between genetic factors and ALS progression rate is not clear. In this study, we carried out a causal...
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