Article

The oligogenic structure of amyotrophic lateral sclerosis has genetic testing, counselling, and therapeutic implications

2024-03-26

Abstract excerpt

Recently, large-scale case-control analyses have been prioritized in the study of ALS. Yet the same effort has not been put forward to investigate additive moderate phenotypic effects of genetic variants in genes driving ALS risk, despite case-level evidence suggesting a potential oligogenic risk model. Considering its direct clinical and therapeutic implications, a large-scale robust investigation of oligogenicit...

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Literature Corpus work: f5bf2082-a472-5a90-9cfc-ddd07ba7d9e8
DOI: 10.1101/2024.03.21.24304693

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