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Article

Dissection of genetic factors associated with amyotrophic lateral sclerosis.

Experimental neurology - 1 Dec 2014

Leblond Claire S, Kaneb Hannah M, Dion Patrick A, Rouleau Guy A

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal late onset neurological disorder characterized by motor neuron degeneration in the primary motor cortex, brainstem and spinal cord. The majority of cases are sporadic (SALS) and only 5-10% have a family history (FALS). FALS cases show a high heritability and this has enabled the identification of several genetic triggers, of which mutations in SOD1, FUS, TARDBP and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24780888
DOI: 10.1016/j.expneurol.2014.04.013

Genes

FUS
SOD1
TARDBP

Provenance

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