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Article

Association between the APOEε4 Allele and Late-Onset Alzheimer’s Disease in an Ecuadorian Mestizo Population

1 Jan 2017

Abstract excerpt

Alzheimer’s disease (AD) is the most common neurodegenerative disease. It has two main pathological hallmarks: amyloid plaques and neurofibrillary tangles. The APOEε4 allele has been recognized as the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD) in several populations worldwide, yet the risk varies by region and ethnicity. The aims of this study were to describe APOE allele and genotype...

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PMID: 29348964
DOI: 10.1155/2017/1059678

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