Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis.

doi:10.1016/j.jaci.2013.01.052

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Article

Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis.

The Journal of allergy and clinical immunology - 1 Jun 2013

Sampaio Elizabeth P, Hsu Amy P, Pechacek Joseph, Bax Hannelore I, Dias Dalton L, Paulson Michelle L, Chandrasekaran Prabha, Rosen Lindsey B, Carvalho Daniel S, Ding Li, Vinh Donald C, Browne Sarah K, Datta Shrimati, Milner Joshua D, Kuhns Douglas B, Long Priel Debra A, Sadat Mohammed A, Shiloh Michael, De Marco Brendan, Alvares Michael, Gillman Jason W, Ramarathnam Vivek, de la Morena Maite, Bezrodnik Liliana, Moreira Ileana, Uzel Gulbu, Johnson Daniel, Spalding Christine, Zerbe Christa S, Wiley Henry, Greenberg David E, Hoover Susan E, Rosenzweig Sergio D, Galgiani John N, Holland Steven M

Abstract excerpt

BACKGROUND: Impaired signaling in the IFN-γ/IL-12 pathway causes susceptibility to severe disseminated infections with mycobacteria and dimorphic yeasts. Dominant gain-of-function mutations in signal transducer and activator of transcription 1 (STAT1) have been associated with chronic mucocutaneous candidiasis. OBJECTIVE: We sought to identify the molecular defect in patients with disseminated dimorphic yeast...

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Identifiers

PMID: 23541320
DOI: 10.1016/j.jaci.2013.01.052
PMCID: PMC3746066

Genes

STAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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