Paracoccidioidomycosis Associated With a Heterozygous STAT4 Mutation and Impaired IFN-γ Immunity.

doi:10.1093/infdis/jix522

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Article

Paracoccidioidomycosis Associated With a Heterozygous STAT4 Mutation and Impaired IFN-γ Immunity.

The Journal of infectious diseases - 19 Dec 2017

Schimke Lena F, Hibbard James, Martinez-Barricarte Ruben, Khan Taj Ali, de Souza Cavalcante Ricardo, Borges de Oliveira Junior Edgar, Takahashi França Tabata, Iqbal Asif, Yamamoto Guilherme, Arslanian Christina, Feriotti Claudia, Costa Tania Alves, Bustamante Jacinta, Boisson-Dupuis Stéphanie, Casanova Jean-Laurent, Marzagao Barbuto José Alexandre, Zatz Mayana, Poncio Mendes Rinaldo, Garcia Calich Vera Lucia, Ochs Hans D, Torgerson Troy R, Cabral-Marques Otávio, Condino-Neto Antonio

Abstract excerpt

Background: Mutations in genes affecting interferon-γ (IFN-γ) immunity have contributed to understand the role of IFN-γ in protection against intracellular pathogens. However, inborn errors in STAT4, which controls interleukin-12 (IL-12) responses, have not yet been reported. Our objective was to determine the genetic defect in a family with a history of paracoccidioidomycosis. Methods: Genetic analysis was...

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PMID: 29029192
DOI: 10.1093/infdis/jix522

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STAT4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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