Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caloric restriction in humans reveals immunometabolic regulators of health span

10 Feb 2022

Abstract excerpt

The extension of life span driven by 40% caloric restriction (CR) in rodents causes trade-offs in growth, reproduction, and immune defense that make it difficult to identify therapeutically relevant CR-mimetic targets. We report that about 14% CR for 2 years in healthy humans improved thymopoiesis and was correlated with mobilization of intrathymic ectopic lipid. CR-induced transcriptional reprogramming in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Fatty Acid Research and Health
Share to Inflammasome and immune disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35143297
DOI: 10.1126/science.abg7292

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caloric restriction in humans reveals immunometabolic regulators of health spanPMID 35143297Read ↗

Interferon regulatory factor 7 impairs cellular metabolism in aging adipose-derived stromal cellsSemantic proximity Read ↗

Caloric restriction reprograms adipose tissues in rhesus monkeysSemantic proximity Read ↗

Shifts of Immune Cell Populations Differ in Response to Different Effectors of Beige Remodeling of Adipose TissueSemantic proximity Read ↗

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic PotentialSemantic proximity Read ↗

Age-dependent disease tolerance to SARS-CoV-2 infectionSemantic proximity Read ↗

The fine line between lifespan extension and shortening in response to caloric restrictionSemantic proximity Read ↗

Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from TuberculosisSemantic proximity Read ↗

Metabolic Reprogramming by Reduced Calorie Intake or Pharmacological Caloric Restriction Mimetics for Improved Cancer ImmunotherapySemantic proximity Read ↗

Altered basal lipid metabolism underlies the functional impairment of naive CD8 <sup>+</sup> T cells in elderly humansSemantic proximity Read ↗

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolismSemantic proximity Read ↗

Quantitative analysis and genome-scale modeling of human CD4 <sup>+</sup> T-cell differentiation reveals subset-specific regulation of glycosphingolipid pathwaysSemantic proximity Read ↗

Caloric restriction has a new playerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.