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Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target

9 Feb 2022

Abstract excerpt

A major rate-limiting step in developing more effective immunotherapies for GBM is our inadequate understanding of the cellular complexity and the molecular heterogeneity of immune infiltrates in gliomas. Here, we report an integrated analysis of 201,986 human glioma, immune, and other stromal cells at the single cell level. In doing so, we discover extensive spatial and molecular heterogeneity in immune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35140215
DOI: 10.1038/s41467-022-28372-y

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