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Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution

11 Mar 2021

Abstract excerpt

In recognizing the host cellular receptor and mediating fusion of virus and cell membranes, the spike (S) glycoprotein of coronaviruses is the most critical viral protein for cross-species transmission and infection. Here we determined the cryo-EM structures of the spikes from bat (RaTG13) and pangolin (PCoV_GX) coronaviruses, which are closely related to SARS-CoV-2. All three receptor-binding domains (RBDs) of...

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PMID: 33707453
DOI: 10.1038/s41467-021-21767-3

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