Article

CACNA1C TS-II variants alter single-cell dynamics in computational models of cortical pyramidal cells

2025-07-03

Abstract excerpt

Timothy Syndrome (TS) is a rare multi-system disorder and a monogenic calcium channelopathy. Previous computational work on this disorder has focused on the myocardium, ignoring the effects of TS on neural development and its strong association with autism spectrum disorder. Variation in the TS-causative gene, CACNA1C , is indeed also associated with a variety of complex neurodevelopmental and neuropsychiatric di...

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Literature Corpus work: 3503146a-6da1-55d4-a54a-54b2871f6ec9
DOI: 10.1101/2025.07.02.662758

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