Article
Piperaquine resistant Cambodian Plasmodium falciparum clinical isolates: in vitro genotypic and phenotypic characterization.
Malaria journal - 25 Jul 2020
Boonyalai Nonlawat, Vesely Brian A, Thamnurak Chatchadaporn, Praditpol Chantida, Fagnark Watcharintorn, Kirativanich Kirakarn, Saingam Piyaporn, Chaisatit Chaiyaporn, Lertsethtakarn Paphavee, Gosi Panita, Kuntawunginn Worachet, Vanachayangkul Pattaraporn, Spring Michele D, Fukuda Mark M, Lon Chanthap, Smith Philip L, Waters Norman C, Saunders David L, Wojnarski Mariusz
Abstract excerpt
BACKGROUND: High rates of dihydroartemisinin-piperaquine (DHA-PPQ) treatment failures have been documented for uncomplicated Plasmodium falciparum in Cambodia. The genetic markers plasmepsin 2 (pfpm2), exonuclease (pfexo) and chloroquine resistance transporter (pfcrt) genes are associated with PPQ resistance and are used for monitoring the prevalence of drug resistance and guiding malaria drug treatment policy....
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