An adaptive combination method for Cauchy variable based on optimal threshold.

Abstract excerpt

In sequence study, set-based analysis has been developed as a popular tool for analysing the association of a group rare variant with disease. However, most of the methods are sensitive to the genetic architecture. Besides, by directly combining the association signals of multiple markers within a genomic region can inevitably include a large proportion of noises. To address this issue, we extend the aggregated...

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