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Article

Adaptive combination of Bayes factors as a powerful method for the joint analysis of rare and common variants.

Scientific reports - 24 Oct 2017

Lin Wan-Yu, Chen Wei J, Liu Chih-Min, Hwu Hai-Gwo, McCarroll Steven A, Glatt Stephen J, Tsuang Ming T

Abstract excerpt

Multi-marker association tests can be more powerful than single-locus analyses because they aggregate the variant information within a gene/region. However, combining the association signals of multiple markers within a gene/region may cause noise due to the inclusion of neutral variants, which usually compromises the power of a test. To reduce noise, the "adaptive combination of P-values" (ADA) method removes...

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PMID: 29066733
DOI: 10.1038/s41598-017-13177-7
PMCID: PMC5654754

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