Article
Adaptive tests for association analysis of rare variants.
Genetic epidemiology - 1 Jul 2011
Pan Wei, Shen Xiaotong
Abstract excerpt
In anticipation of the availability of next-generation sequencing data, there has been increasing interest in association analysis of rare variants (RVs). Owing to the extremely low frequency of a RV, single variant-based analysis and many existing tests developed for common variants may not be suitable. Hence, it is of interest to develop powerful statistical tests to assess association between complex traits...
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