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HBD-2 binds SARS-CoV-2 RBD and blocks viral entry: Strategy to combat COVID-19

2 Feb 2022

Abstract excerpt

New approaches to complement vaccination are needed to combat the spread of SARS-CoV-2 and stop COVID-19-related deaths and medical complications. Human beta defensin 2 (hBD-2) is a naturally occurring epithelial cell-derived host defense peptide that has anti-viral properties. Our comprehensive in-silico studies demonstrate that hBD-2 binds the site on the CoV-2-RBD that docks with the ACE2 receptor. Biophysical...

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PMID: 35128350
DOI: 10.1016/j.isci.2022.103856

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