Article

Evolving principles underlying neural lineage conversion and their relevance for biomedical translation

2019-08-30

Abstract excerpt

Scientific and technological advances of the past decade have shed light on the mechanisms underlying cell fate acquisition, including its transcriptional and epigenetic regulation during embryonic development. This knowledge has enabled us to purposefully engineer cell fates in vitro by manipulating expression levels of lineage-instructing transcription factors. Here, we review the state of the art in the cell pr...

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Literature Corpus work: 04f302f0-b280-55fc-a08e-f5909d6af5f3
DOI: 10.12688/f1000research.18926.1

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