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Structural Comparison of HIV-1 Envelope Spikes with and without the V1/V2 Loop

30 Dec 2010

Abstract excerpt

We have used cryoelectron tomography of vitreous-ice-embedded HIV-1 virions to compare the envelope (Env) spikes of a wild-type strain with those of a mutant strain in which the V1/V2 loop has been deleted. Deletion of V1/V2 results in a spike with far more structural heterogeneity than is observed in the wild type, likely reflecting greatly enhanced gp120 protomer flexibility. A major difference between the two...

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PMID: 21191026
DOI: 10.1128/jvi.01612-10

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