Article
Cryoelectron Tomography of HIV-1 Envelope Spikes: Further Evidence for Tripod-Like Legs
13 Nov 2008
Abstract excerpt
A detailed understanding of the morphology of the HIV-1 envelope (Env) spike is key to understanding viral pathogenesis and for informed vaccine design. We have previously presented a cryoelectron microscopic tomogram (cryoET) of the Env spikes on SIV virions. Several structural features were noted in the gp120 head and gp41 stalk regions. Perhaps most notable was the presence of three splayed legs projecting...
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