Article
Expression quantitative trait loci (eQTLs) in human placentas suggest developmental origins of complex diseases.
Human molecular genetics - 1 Sept 2017
Peng Shouneng, Deyssenroth Maya A, Di Narzo Antonio F, Lambertini Luca, Marsit Carmen J, Chen Jia, Hao Ke
Abstract excerpt
Epidemiologic studies support that at least part of the risk of chronic diseases in childhood and even adulthood may have an in utero origin, and the placenta is a key organ that plays a pivotal role in fetal growth and development. The transcriptomes of 159 human placenta tissues were profiled by genome-wide RNA sequencing (Illumina High-Seq 2500), and linked to fetal genotypes assessed by a high density single...
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