Article
Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients.
Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2007
Ráki Melinda, Fallang Lars-Egil, Brottveit Margit, Bergseng Elin, Quarsten Hanne, Lundin Knut E A, Sollid Ludvig M
Abstract excerpt
Tetramers of MHC-peptide complexes are used for detection and characterization of antigen-specific T cell responses, but they require knowledge about both antigenic peptide and the MHC restriction element. The successful application of these reagents in human diseases involving CD4+ T cells is limited. Celiac disease, an intestinal inflammation driven by mucosal CD4+ T cells recognizing wheat gluten peptides in...
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