Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasia

7 Oct 2023

Abstract excerpt

Abstract M3 muscarinic receptors (M3R) modulate β-catenin signaling and colon neoplasia. CDC42/RAC guanine nucleotide exchange factor, βPix, binds to β-catenin in colon cancer cells, augmenting β-catenin transcriptional activity. Using in silico, in vitro, and in vivo approaches, we explored whether these actions are regulated by M3R. At the invasive fronts of murine and human colon cancers, we detected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Galectins and Cancer Biology
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37805544
DOI: 10.1038/s41598-023-44158-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasiaPMID 37805544Read ↗

Overcoming Obstacles to Targeting Muscarinic Receptor Signaling in Colorectal CancerSemantic proximity Read ↗

β2-Chimaerin Deficiency Favors Polyp Growth in the Colon of Apc<sup>Min/+</sup> MiceSemantic proximity Read ↗

Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and InvasionSemantic proximity Read ↗

Mesalazine initiates an anti-oncogenic β-catenin / MUCDHL negative feed-back loop in colon cancer cells by cell-specific mechanismsSemantic proximity Read ↗

Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferationSemantic proximity Read ↗

Pleotropic effects of PPARD accelerate colorectal tumor progression and invasionSemantic proximity Read ↗

NR4A1 modulates intestinal smooth muscle cell phenotype and dampens inflammation-associated intestinal remodeling.Semantic proximity Read ↗

Genetic Ablation of M3 Muscarinic Receptors Attenuates Murine Colon Epithelial Cell Proliferation and NeoplasiaSemantic proximity Read ↗

Wnt breakers in colon cancer.Semantic proximity Read ↗

Aberrant Wnt/β-catenin signaling can induce chromosomal instability in colon cancerSemantic proximity Read ↗

CDC42 Inhibition Suppresses Progression of Incipient Intestinal TumorsSemantic proximity Read ↗

KITENIN recruits Dishevelled/PKC delta to form a functional complex and controls the migration and invasiveness of colorectal cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.