Article

Apoptosis-resistance of senescent cells is an intrinsic barrier for senolysis induced by cardiac glycosides

2020-12-20

Abstract excerpt

<h4>ABSTRACT</h4> Targeted elimination of senescent cells – senolysis – is one of the core trends in the anti-aging therapy. Cardiac glycosides were recently proved to be a broad-spectrum senolytics. Here we tested senolytic properties of cardiac glycosides towards human mesenchymal stem cells (hMSCs). Cardiac glycosides had no senolytic ability towards senescent hMSCs of various origins. Using biological and bio...

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Literature Corpus work: d55ea32b-f749-54db-b9c6-81477a3f39e6
DOI: 10.1101/2020.12.18.423449

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