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Article

Integrating multiple protein-protein interaction networks to prioritize disease genes: a Bayesian regression approach.

BMC bioinformatics - 15 Feb 2011

Zhang Wangshu, Sun Fengzhu, Jiang Rui

Abstract excerpt

BACKGROUND: The identification of genes responsible for human inherited diseases is one of the most challenging tasks in human genetics. Recent studies based on phenotype similarity and gene proximity have demonstrated great success in prioritizing candidate genes for human diseases. However, most of these methods rely on a single protein-protein interaction (PPI) network to calculate similarities between genes,...

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PMID: 21342540
DOI: 10.1186/1471-2105-12-S1-S11
PMCID: PMC3044265

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