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A common TMPRSS2 variant has a protective effect against severe COVID-19

10 Jan 2022

Abstract excerpt

Background The human protein transmembrane protease serine type 2 (TMPRSS2) plays a key role in SARS-CoV-2 infection, as it is required to activate the virus’ spike protein, facilitating entry into target cells. We hypothesized that naturally-occurring TMPRSS2 human genetic variants affecting the structure and function of the TMPRSS2 protein may modulate the severity of SARS-CoV-2 infection. Methods We focused on...

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PMID: 35104687
DOI: 10.1016/j.retram.2022.103333

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