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Article

Protective Role of a TMPRSS2 Variant on Severe COVID-19 Outcome in Young Males and Elderly Women.

Genes - 19 Apr 2021

Monticelli Maria, Hay Mele Bruno, Benetti Elisa, Fallerini Chiara, Baldassarri Margherita, Furini Simone, Frullanti Elisa, Mari Francesca, Andreotti Giuseppina, Cubellis Maria Vittoria, Renieri Alessandra

Abstract excerpt

The protease encoded by the TMPRSS2 gene facilitates viral infections and has been implicated in the pathogenesis of SARS-CoV-2. We analyzed the TMPRSS2 sequence and correlated the protein variants with the clinical features of a cohort of 1177 patients affected by COVID-19 in Italy. Nine relatively common variants (allele frequency > 0.01) and six missense variants which may affect the protease activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33921689
DOI: 10.3390/genes12040596
PMCID: PMC8073081

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