Article

A Common <i>TMPRSS2</i> Variant Protects Against Severe COVID-19

2021-03-12

Abstract excerpt

Background: The human protein transmembrane protease serine type 2 (TMPRSS2) plays a key role in SARS-CoV-2 infection, as it is required to activate the virus’ spike protein, facilitating entry into target cells. We hypothesized that naturally-occurring <i>TMPRSS2</i> human genetic variants affecting the structure and function of the TMPRSS2 protein may modulate the severity of SARS-CoV-2 infection.<br><br>Methods...

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Literature Corpus work: e9ed21fe-c3f8-5c10-8893-b56792ed602a
DOI: 10.2139/ssrn.3803364

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