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Article

Dynamic increase of M2 macrophages is associated with disease progression of colorectal cancers following cetuximab-based treatment.

Scientific reports - 31 Jan 2022

Kim Hyung-Don, Kim Sun Young, Kim Jihun, Kim Jeong Eun, Hong Yong Sang, Han Buhm, Tak Eunyoung, Ryu Yeon-Mi, Kim Sang-Yeob, Kim Tae Won

Abstract excerpt

We aimed to investigate the dynamic changes of gene expression profiles and immune microenvironment linked to resistance to cetuximab-based treatments in patients with metastatic colorectal cancer (mCRC). A total of 106 patients with RAS-wild type mCRC who were treated with cetuximab-based treatments were included as the study population. RNA-sequencing and multiplexed immunohistochemistry were performed using...

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Share to Antigens, CD
Share to Antigens, Differentiation, Myelomonocytic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antineoplastic Agents, Immunological

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Source

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Identifiers

PMID: 35102212
DOI: 10.1038/s41598-022-05694-x
PMCID: PMC8803829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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