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Article

The clinical aspect of NTRK-fusions in pediatric papillary thyroid cancer.

Cancer genetics - 1 Apr 2022

Ricarte-Filho Julio C, Halada Stephen, O'Neill Alison, Casado-Medrano Victoria, Laetsch Theodore W, Franco Aime T, Bauer Andrew J

Abstract excerpt

Although adult and pediatric papillary thyroid cancer (PTC) share similar oncogenic drivers, they differ in the pathological features and outcomes of the disease. In adults with PTC, the most frequent genetic alterations are mutually exclusive point mutations in BRAFV600E or the RAS family with BRAFV600E commonly associated with invasive disease and decreased response to radioiodine therapy. In pediatric PTC,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35092884
DOI: 10.1016/j.cancergen.2022.01.002
PMCID: PMC8931989

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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