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Article

NTRK-fusions in pediatric thyroid tumors: Current state and future perspectives.

Cancer genetics - 1 Jun 2022

Casado-Medrano Victoria, O'Neill Alison, Halada Stephen, Laetsch Theodore W, Bauer Andrew J, Franco Aime T

Abstract excerpt

Pediatric and adult papillary thyroid cancer (PTC) share many similar oncogenic drivers, but differ in the pathological features and outcomes of the disease. The most frequent genetic alterations in adult PTCs are mutually exclusive point mutations in BRAF or the RAS family. In pediatric PTC, fusion oncogenes involving chromosomal translocations in tyrosine kinase (TK) receptors, most commonly RET and NTRK, are...

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Identifiers

PMID: 35290879
DOI: 10.1016/j.cancergen.2022.02.009
PMCID: PMC9133211

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