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Article

Plasmodium falciparum Kelch13 and its artemisinin-resistant mutants assemble as hexamers in solution: a SAXS data-driven modelling study.

The FEBS journal - 1 Aug 2022

Goel Nainy, Dhiman Kanika, Kalidas Nidhi, Mukhopadhyay Anwesha, Ashish Fnu, Bhattacharjee Souvik

Abstract excerpt

The artemisinin-resistant mutations in Plasmodium falciparum (PfKelch13) identified worldwide are mostly confined to the Broad-complex, tramtrack and bric-à-brac/poxvirus and zinc-finger (BTB/POZ) and Kelch-repeat propeller (KRP) domains. To date, only two crystal structures of the BTB/POZ-KRP domains as tight dimers are available, which limits structure-based predictions and interpretation of its role(s) in...

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PMID: 35092154
DOI: 10.1111/febs.16378

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