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Article

The double-edged sword of PI3Kδ pathway-related immune dysregulation: insights from two case reports.

Immunologic research - 19 Sept 2025

Cabanero-Navalon Marta Dafne, Garcia-Bustos Victor, Ibanez-Barcelo Santos, Balastegui-Martin Héctor, Grimaldos-Lodares Javier, Moral-Moral Pedro

Abstract excerpt

Phosphoinositide 3-kinases (PI3Ks), particularly the PI3Kδ pathway, play a crucial role in regulating immune functions. Alterations in this pathway, either as hyperactivation, such as in activated PI3Kδ syndrome (APDS), or rarely described hypoactivation, profoundly influence immune function and are linked to a spectrum of immunodeficiencies and autoimmune conditions. This report describes two cases of late-onset...

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Share to Class I Phosphatidylinositol 3-Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40971032
DOI: 10.1007/s12026-025-09691-w
PMCID: PMC12449316

Genes

PIK3CD

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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