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Article

Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases.

Frontiers in immunology - 1 Jan 2018

Dornan Gillian L, Burke John E

Abstract excerpt

The signaling lipid phosphatidylinositol 3,4,5, trisphosphate (PIP3) is an essential mediator of many vital cellular processes, including growth, survival, and metabolism. PIP3 is generated through the action of the class I phosphoinositide 3-kinases (PI3K), and their activity is tightly controlled through interactions with regulatory proteins and activating stimuli. The class IA PI3Ks are composed of three...

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Identifiers

PMID: 29616047
DOI: 10.3389/fimmu.2018.00575
PMCID: PMC5868324

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